We have developed a Bioactive Glass technology, DentoClude (Occlude Dentin Tubule) Agents( US FDA approved and available only by prescription), used in tooth restoration process to help prevent micro-leakage and prevent sensitivity caused by micro-leakage. DentoClude Indications for Use: Desensitizing agent for dentin surfaces by blocking dentin tubules to help prevent micro-leakage. Use under direct or indirect restorations following dentin etch and prior to dentin adhesive application. Desensitizing agent for use in treatment of cervical erosion in Class V restorations. Additionally, DentoClude technology composition includes phytoceutical excipients as part of its formulation to further prevents periodontal disease.
The prevalence of dentinal hypersensitivity has been reported over the years in a variety of ways: greater than 40 million people in the U.S. annually, 14.3% of all dental patients, between 8% and 57% of adult dentate population, and up to 30% of adults at some time during their lifetime.(Reference: Desensitizing bioactive agents improves bond strength of indirect resin-cemented restorations: preliminary results Fernanda de Carvalho Panzeri Pires-de-SouzaI; FabĂola Fiorezi de MarcoII; Luciana Assirati CasemiroIII; Heitor PanzeriI).
Dentin hypersensitivity (DH) is characterized as sharp and short-lasting dental pain to a tactile, chemical, osmotic, evaporative, or thermal stimulus. DH may be elicited by exposed dentin due to erosion, attrition, abfraction, abrasion, gingival recession, or periodontal disease.
DH is the hydrodynamic theory in which stimuli induce fluid movement in the dentinal tubules causing mechanoreceptors close to the pulp to excite the nerve terminals fibers resulting in the perception of the characteristic pain. DH, based on the hydrodynamic theory, can either be managed by blocking nerve excitation or by sealing the dentinal tubules. Excitation is proposed to be blocked by raising the extracellular concentration of potassium ions around the nerve fibers, which blocks repolarization thereby preventing the generation of the action potential. Occlusion of open dentinal tubules reduces the dentinal fluid flow
Bioactive glass interact with the biological environment to elicit a specific biological response, such as the formation of a hydroxyapatite layer with a bond forming between the tissue and material. Bone and teeth, enamel and dentin, consist mainly of mineralized hard tissue in the form of hydroxyapatite, a crystalline calcium phosphate. Bioactive glass has a superior surface area with a higher dissolution rate and thus faster apatite formation and have shown to increase the mechanical properties of such composite for natural bones and provide biomimetic nano-structuration enhancing cell adhesion. (Reference: Bioactive Glass Applications in Dentistry Hans Erling Skallevold,1 Dinesh Rokaya,2,3,* Zohaib Khurshid,4 and Muhammad Sohail Zafa)